Scientist, Analytical Chemistry (siRNAs, mRNAs, LNPs, AAVs, CRISPR-Cas)

Job Details:-

This is a job posting from company – Regeneron Pharmaceuticals

Employment TypeFull Time

Work Hours: 8

Salary: $20 To $30/An Hour

Location: New York, USA

This job is 100% remote.

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Our Analytical Chemistry Group (ACG) at Regeneron is seeking a highly motivated Scientist/Senior Scientist in support of Regeneron Genetics Medicines (RGM) development. We work in a mass spectrometry lab and focuses on the biochemical characterization of emerging novel therapeutic modalities as well as therapeutic monoclonal antibodies at all stages of development. In this role, you will develop LC-MS methods and/or other analytical strategies for elucidating and characterizing novel therapeutics (oligonucleotides, siRNAs, mRNAs, LNPs, AAVs, CRISPR-Cas, etc) and antibody attributes such as primary structures, disulfide linkages, PTMs, product and process related impurities, charge/size variants, sequence variants, etc. You will conduct analytical method qualification for late-stage antibody and/or RGM drug development programs and develop innovative technologies to support a diverse Regeneron’s R&D pipeline.

A Typical Day In This Role Looks Like:

Develop LC-MS based analytical methods to support RGM novel therapeutics development as well as the development of monoclonal antibody-based therapeutic proteins and inform critical quality attributes, develop ability assessment and risk mitigation strategies in collaboration with other CMC teams.

Perform LC-MS data analysis using various software and bioinformatic tools to elucidate the quality attributes of therapeutic proteins and other novel modalities.

Assume a leading role to support R&D activities and regulatory applications and deepen our knowledge of antibody therapeutics and other emerging novel modalities.

Lead sample preparation and LC-MS-based experiments based on SOPs and document experiments, results and findings in electronic laboratory notebook (ELN) entries; present data at group and project meetings; write technical reports, SOPs, and regulatory filing reports, etc.

Summarize results in a concise format (graphs, figures, tables, etc.) to support presentations, peer-reviewed publications, and regulatory documents, etc.

This Role May Be For You If:

You have knowledge and hands-on experience in LC-MS based sample preparation for proteins and peptides are preferred. Experience in quantitative proteomics is preferred.

A consistent record of publication in the field of LC-MS is a strong plus. Experience with automated liquid handling system (Biomek, Bravo, King Fisher, Tecan, etc) is a plus. Experience with DoE, molecular modeling, graphing and statistical analysis software is a plus.

Strong verbal and written communication skills as well as good interpersonal skills are essential. The ability to learn new technologies and solve problems is essential. A passion for science and motivation to contribute in a team environment is necessary.

This role is for you if you are motivated, results-driven, efficient, and able to perform key responsibilities in an innovative, fast-paced, team environment.

To be considered for this role, you must have a PhD degree in Chemistry, Biochemistry, Analytical Chemistry, Pharmaceutical Sciences, or a related field with 0-3 years of post-doctoral or industrial experience, or a MS degree with 3-8 years of work experience in analytical characterization of antibodies, ADCs, protein therapeutics, oligonucleotides, siRNAs, mRNAs, LNPs, AAVs, CRISPR-Cas, and other therapeutic modalities.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.

The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.

Salary Range (annually) $103,600.00 – $169,000.00


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